Cesium carbonate → 4-Imidazol-1-ylmethyl-2-[2-(2-oxo-2H-pyridin-1-yl)-phenoxy]-benzonitrile

참여 물질

역할	이름	HCID	투입량
반응물	Cesium carbonate	HCID 10796	—
반응물	2-(2-oxo-2H-pyridin-1-yl)-phenol	HCID 21697056	—
반응물	Benzonitrile, 2-fluoro-4-(1H-imidazol-1-ylmethyl)-	HCID 21697068	—
용매	Dimethylformamide	HCID 6228	—
생성물	4-Imidazol-1-ylmethyl-2-[2-(2-oxo-2H-pyridin-1-yl)-phenoxy]-benzonitrile	HCID 9951152	—

반응 조건

온도	70 °C

반응 단계

2-Fluoro-4-imidazol-1-ylmethyl-benzonitrile (as described in Example 9, Step E) (0.0276 g, 0.137 mmol), 2-(2-oxo-2H-pyridin-1-yl)-phenol (0.0257 g, 0.137 mmol) and cesium carbonate (0.089 g, 0.274 mmol) were combined in DMF (1.2 mL) and heated at 70° C. for 18 hr. The title compound was obtained after RP HPLC on aWaters Prep Pak column eluting with a 0.1% TFA/H2O: 0.1% TFA/CH3CN gradient followed by conversion to the free base.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06297239B1
출처 데이터셋	uspto-grants-2001_10
ORD ID	ord-899750f8795945f4ba7065d7861781cd
출처 메모	uspto-grants-2001_10