3-Aminoazetidine, 3-BOC protected → tert-Butyl {1-[6-(5-oxo-4-pyridin-3-yl-2,5-dihydro-1H-pyrazol-1-yl)pyrimidin-4-yl]azetidin-3-yl}-carbamate

HRID 37911

반응식

HRID 37911 반응식
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([N:8]2[C:12](=[O:13])[C:11]([C:14]3[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=3)=[CH:10][NH:9]2)[CH:3]=1.[NH:20]1[CH2:23][CH:22]([NH:24][C:25](=[O:31])[O:26][C:27]([CH3:30])([CH3:29])[CH3:28])[CH2:21]1>C(O)C>[O:13]=[C:12]1[N:8]([C:4]2[N:5]=[CH:6][N:7]=[C:2]([N:20]3[CH2:23][CH:22]([NH:24][C:25](=[O:31])[O:26][C:27]([CH3:29])([CH3:28])[CH3:30])[CH2:21]3)[CH:3]=2)[NH:9][CH:10]=[C:11]1[C:14]1[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=1

참가 물질

4

반응물 2

HCID 15194053-Aminoazetidine, 3-BOC protectedHCID 866723282-(6-Chloropyrimidin-4-yl)-4-pyridin-3-yl-1,2-dihydro-3H-pyrazol-3-one

생성물 1

HCID 70302327tert-Butyl {1-[6-(5-oxo-4-pyridin-3-yl-2,5-dihydro-1H-pyrazol-1-yl)pyrimidin-4-yl]azetidin-3-yl}-carbamate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

200 mg (0.7 mmol) of the compound from Example 23 and 252 mg (1.5 mmol) of tert-butyl azetidin-3-ylcarbamate are suspended in 6 ml of ethanol and reacted at 120° C. in a single-mode microwave oven (CEM Explorer) for 40 min. The solid formed is filtered off, washed twice with in each case 0.5 ml of ethanol and dried under high vacuum.

후처리

  1. customreacted at 120° C. in a single-mode microwave oven (CEM Explorer) for 40 min
  2. customThe solid formed
  3. filtrationis filtered off
  4. washwashed twice with in each case 0.5 ml of ethanol
  5. customdried under high vacuum

출처 및 근거

ORD 기록
ord-61ffad6f04f34b6db1d26cca5588c567
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524699B2

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