Sodium Azide → HCID 21698563, 화합물

HRID 379335

반응식

HRID 379335 반응식
Br[CH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[CH2:3]1.[N-:12]=[N+:13]=[N-:14].[Na+]>CN(C=O)C>[N:12]([CH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[CH2:3]1)=[N+:13]=[N-:14]

참가 물질

4

반응물 2

HCID 33557Sodium AzideHCID 117459123-Bromo-1-indanone

생성물 1

HCID 21698563HCID 21698563, 화합물수율 86%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a stirring solution of 3-Bromo indan-1-one (400 mg, 1.90 mmol) in DMF (5 ml) was added sodium azide (1.98 g, 0.03 mol). The reaction was allowed to stir at room temperature for 15 mins. The product was partitioned between water (10 ml) and ether (10 ml). The ether layers were combined and the crude reaction mixture was passed through a plug of flash silica, eluting with petroleum ether:ethyl acetate (9:1). The product was isolated as an orange oil (283 mg, 86%).

후처리

  1. customThe product was partitioned between water (10 ml) and ether (10 ml)
  2. customthe crude reaction mixture
  3. washeluting with petroleum ether:ethyl acetate (9:1)

출처 및 근거

ORD 기록
ord-eed564b2fbf242f284c2735251596e23
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06297399B1

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