참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | (+)-Methyl lactate | HCID 637514 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | (R)-2-Hydroxy-1-morpholinopropan-1-one | HCID 14978393 | 87% |
반응 단계
A mixture of methyl (R)-lactate (175 g) and morpholine (440 ml, 3 eq) was heated at 85° C. for 40 h. The mixture was evaporated under reduced pressure. Purification of the residue by silica gel chromatography (using n-hexane:ethyl acetate=1:1 ˜ethyl acetate as an eluent) gave 4-[(R)-2-hydroxypropionyl]morpholine (232.4 g, 87% yield) as a pale yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06300353B1 |
|---|
| 출처 데이터셋 | uspto-grants-2001_10 |
|---|
| ORD ID | ord-94c4aacdfda3451caec808415054f4a0 |
|---|
| 출처 메모 | uspto-grants-2001_10 |
|---|
