2-Bromo-1-(thiophen-2-yl)ethan-1-one → 3-Amino-6-chloro-1-(ethoxycarbonyl)-2-(thiophene-2-carbonyl)indole

반응식

[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([NH:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:3]=1.Br[CH2:17][C:18]([C:20]1[S:21][CH:22]=[CH:23][CH:24]=1)=[O:19]>>[NH2:7][C:6]1[C:5]2[C:4](=[CH:3][C:2]([Cl:1])=[CH:9][CH:8]=2)[N:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:17]=1[C:18]([C:20]1[S:21][CH:22]=[CH:23][CH:24]=1)=[O:19]

참가 물질

반응물 2

HCID 27763722-Bromo-1-(thiophen-2-yl)ethan-1-one

HCID 183678884-Chloro-2-[(ethoxycarbonyl)amino]benzonitrile

생성물 1

HCID 183680893-Amino-6-chloro-1-(ethoxycarbonyl)-2-(thiophene-2-carbonyl)indole

실험 절차

The title compound was prepared according to the procedure described in step 2 of Example 1 from 4-chloro-2-(ethoxycarbonylamino)benzonitrile (Example 1, step 1) and 2-(bromoacetyl)thiophene (Steinkopt, Justus Liebig Ann. Chem., 1923, 430, 103).

출처 및 근거

ORD 기록: ord-d93faaded64c421da127d555d7bcbf6e
출처 데이터셋: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06300363B1

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