2-Bromo-3'-chloroacetophenone → 3-Amino-5-chloro-2-(3-chlorobenzoyl)-1-(ethoxycarbonyl)indole

HRID 379797

반응식

HRID 379797 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:6]([CH:9]=1)[C:7]#[N:8].Br[CH2:17][C:18]([C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([Cl:26])[CH:21]=1)=[O:19]>>[NH2:8][C:7]1[C:6]2[C:5](=[CH:4][CH:3]=[C:2]([Cl:1])[CH:9]=2)[N:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:17]=1[C:18](=[O:19])[C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([Cl:26])[CH:21]=1

참가 물질

3

반응물 2

HCID 387382-Bromo-3'-chloroacetophenoneHCID 21779762Ethyl 4-chloro-2-cyanophenylcarbamate

생성물 1

HCID 183677413-Amino-5-chloro-2-(3-chlorobenzoyl)-1-(ethoxycarbonyl)indole

실험 절차

The title compound was prepared according to the procedure described in step 2 of Example 1 from 5-chloro-2-(ethoxycarbonylamino)benzonitrile (K. O. Geolotte et al, J. Heterocyclic Chem., 1990, 27, 1549) and 2-bromo-3′-chloroacetophenone (M. Kihara et al., Tetrahedron, 1992, 48, 67-78).

출처 및 근거

ORD 기록
ord-a2ed868e06fb469f9d22b142c6f8ab3f
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06300363B1

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