Triethylamine → HCID 178418517, 화합물

HRID 3798

반응식

HRID 3798 반응식
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([N:11]=[C:12]=[O:13])=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].[ClH:14].Cl.[Cl:16][C:17]1[CH:33]=[CH:32][C:20]([CH2:21][N:22]2[CH2:27][CH2:26][N:25]([CH2:28][CH2:29][CH2:30][SH:31])[CH2:24][CH2:23]2)=[CH:19][CH:18]=1.C(N(CC)CC)C>C(Cl)Cl>[ClH:16].[ClH:14].[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[SH:31][CH2:30][CH2:29][CH2:28][N:25]2[CH2:26][CH2:27][N:22]([CH2:21][C:20]3[CH:19]=[CH:18][C:17]([Cl:16])=[CH:33][CH:32]=3)[CH2:23][CH2:24]2)[OH:13])=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 27963134-Butylphenyl isocyanateHCID 137311183-[4-(4-Chlorobenzyl)piperazin-1-yl]propanethiol dihydrochloride

생성물 1

HCID 178418517HCID 178418517, 화합물수율 56.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The procedure described in Example 2 was followed, using 1.0 g of 4-n-butylphenyl isocyanate, 2.0 g of 3-[4-(4-chlorobenzyl)piperazin-1-yl]propanethiol dihydrochloride, 0.7 g of triethylamine and 50 ml of methylene chloride, to give 0.85 g (28% of theory) of N-(4-n-butylphenyl)-S-{3-[4-(4-chlorobenzyl)piperazin-1-yl]propyl}thiocarbamate dihydrochloride as a white crystalline solid, M.p. 243°-246° C.

출처 및 근거

ORD 기록
ord-fcb401d798df4579a0d7b003226aee98
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04722926

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