Sodium Carbonate → (1S,2R)-4-Fluoro-4'-(2-hydroxy-1-methyl-4-pyridin-3-yl-butoxy)biphenyl-3-carbonitrile

참여 물질

역할	이름	HCID	투입량
반응물	Sodium Carbonate	HCID 10340	—
반응물	5-Bromo-2-fluorobenzonitrile	HCID 2724900	—
반응물	(1S,2R)-4-(2-hydroxy-1-methyl-4-pyridin-3-ylbutoxy)benzeneboronic acid	HCID 54413593	—
촉매	HCID 178418397	HCID 178418397	—
용매	Ethanol	HCID 702	—
생성물	(1S,2R)-4-Fluoro-4'-(2-hydroxy-1-methyl-4-pyridin-3-yl-butoxy)biphenyl-3-carbonitrile	HCID 53853615	—

반응 조건

온도	80 °C

반응 단계

Prepared according to the method described in Example 12 from (1S,2R)-4-(2-hydroxy-1-methyl-4-pyridin-3-ylbutoxy)benzeneboronic acid (0.4 g, Example 33), 3-cyano-4-flurobromobenzene (0.399 g), ethanol (10 ml), 2M aqueous sodium carbonate (1.66 ml) and tetrakis(triphenylphosphine)palladium (0) (0.3 g) with heating at 80° C. for 3 hours. After work-up, the residue was purified by normal-phase HPLC eluting a gradient of 0-10% ethanol in dichloromethane to give the title compound as a solid. (0.24 g).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06300352B1
출처 데이터셋	uspto-grants-2001_10
ORD ID	ord-57fa8a56fc5f40a5ba86f6c4c8cea0aa
출처 메모	uspto-grants-2001_10