Water → 4-Bromo-2,5-difluorobenzenesulfonamide

HRID 380000

반응식

HRID 380000 반응식
[OH-].[NH4+:2].[F:3][C:4]1[CH:9]=[C:8]([Br:10])[C:7]([F:11])=[CH:6][C:5]=1[S:12](Cl)(=[O:14])=[O:13].O>O1CCCC1>[Br:10][C:8]1[C:7]([F:11])=[CH:6][C:5]([S:12]([NH2:2])(=[O:14])=[O:13])=[C:4]([F:3])[CH:9]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 14923Ammonium HydroxideHCID 5745904-Bromo-2,5-difluorobenzenesulfonyl Chloride

생성물 1

HCID 27732934-Bromo-2,5-difluorobenzenesulfonamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Ammonium hydroxide (5 ml) was added to a solution of 2,5-difluoro-4-bromophenylsulfonyl chloride (4.3 g) in tetrahydrofuran (20 ml) at room temperature (CARE:exotherm) and stirred for 10 min. The reaction mixture was poured into water and extracted with ethyl acetate. The ethyl acetate was dried over anhydrous magnesium sulfate and filtered. The filtrate was evaporated and the residue triturated with 20% diethyl ether in isohexane to give the sub-title compound as a solid (4.3 g).

후처리

  1. extractionextracted with ethyl acetate
  2. dry with materialThe ethyl acetate was dried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. customThe filtrate was evaporated
  5. customthe residue triturated with 20% diethyl ether in isohexane

출처 및 근거

ORD 기록
ord-80781d6e4daf441a96141ea53578b925
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06300352B1

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