Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 380001생성일: 2026년 10월 27일
Sodium Carbonate → (1S, 2R)-2,5-Difluoro-4'-(2-hydroxy-1-methyl-4-pyridin-3-yl-butoxy)biphenyl-4-sulfonic acid amide
https://huagongshe.com/reaction/380001
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 4-Bromo-2,5-difluorobenzenesulfonamide | HCID 2773293 | — |
| 반응물 | (1S,2R)-4-(2-hydroxy-1-methyl-4-pyridin-3-ylbutoxy)benzeneboronic acid | HCID 54413593 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | (1S, 2R)-2,5-Difluoro-4'-(2-hydroxy-1-methyl-4-pyridin-3-yl-butoxy)biphenyl-4-sulfonic acid amide | HCID 57221958 | 36.9% |
반응 단계
Prepared according to the method described in Example 12) from (1S,2R)-4-(2-hydroxy-1-methyl-4-pyridin-3-ylbutoxy)benzeneboronic acid (0.2 g, Example 33), 4-bromo-2,5-difluorobenzenesulfonamide (0.19 g, Example 37a)), ethanol (3 ml), 2M aqueous sodium carbonate (0.7 ml) and tetrakis(triphenylphosphine)palladium (0) (0.03 g) with heating at 80° C. for 3 hours. After work-up, the residue was purified by normal-phase HPLC eluting with a gradient of 0-25% ethanol in dichloromethane to give the title compound as a foam (0.11 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06300352B1 |
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| 출처 데이터셋 | uspto-grants-2001_10 |
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| ORD ID | ord-40aa2691177f42fb8a7f311de55bd7c5 |
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| 출처 메모 | uspto-grants-2001_10 |
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