Methanol → Benzene, 1-bromo-3-(methylsulfonyl)-

HRID 380007

반응식

HRID 380007 반응식
[Br:1][C:2]1[CH:3]=[C:4](SC)[CH:5]=[CH:6][CH:7]=1.O[O:11][S:12]([O-:14])=O.[K+].[CH3:16]O>O>[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([S:12]([CH3:16])(=[O:14])=[O:11])[CH:7]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 27356273-BromothioanisoleHCID 23707502Potassium hydroxy sulfite

생성물 1

HCID 2757146Benzene, 1-bromo-3-(methylsulfonyl)-

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

3-Bromothioanisole was dissolved in methanol (20 ml) and cooled to 0° C. (ice/water bath). A solution of Oxone® (9.22 g) in water (30 ml) was added to this and the resultant cloudy slurry was stirred at room temperature for 3 hours. The reaction mixture was diluted with water and product extracted with dichloromethane. The combined fractions of dichloromethane were washed with brine and dried over anhydrous magnesium sulfate. After filtration, solvent was removed by evaporation under reduced pressure to give the sub-title compound as a solid (1.02 g).

후처리

  1. extractionextracted with dichloromethane
  2. washThe combined fractions of dichloromethane were washed with brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. filtrationAfter filtration, solvent
  5. customwas removed by evaporation under reduced pressure

출처 및 근거

ORD 기록
ord-3090aeaf62e34a87881bfec50af3c287
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06300352B1

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