Methanol → Benzene, 1-bromo-3-(methylsulfonyl)-
반응식
[Br:1][C:2]1[CH:3]=[C:4](SC)[CH:5]=[CH:6][CH:7]=1.O[O:11][S:12]([O-:14])=O.[K+].[CH3:16]O>O>[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([S:12]([CH3:16])(=[O:14])=[O:11])[CH:7]=1참가 물질
5
실험 절차
3-Bromothioanisole was dissolved in methanol (20 ml) and cooled to 0° C. (ice/water bath). A solution of Oxone® (9.22 g) in water (30 ml) was added to this and the resultant cloudy slurry was stirred at room temperature for 3 hours. The reaction mixture was diluted with water and product extracted with dichloromethane. The combined fractions of dichloromethane were washed with brine and dried over anhydrous magnesium sulfate. After filtration, solvent was removed by evaporation under reduced pressure to give the sub-title compound as a solid (1.02 g).
후처리
- extractionextracted with dichloromethane
- washThe combined fractions of dichloromethane were washed with brine
- dry with materialdried over anhydrous magnesium sulfate
- filtrationAfter filtration, solvent
- customwas removed by evaporation under reduced pressure
출처 및 근거
- ORD 기록
- ord-3090aeaf62e34a87881bfec50af3c287
- 출처 데이터셋
- uspto-grants-2001_10
- 특허 번호
- US06300352B1
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