Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 5-Bromo-o-toluidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | 4-Bromo-2-nitrotoluene | HCID 123546 | — |
| 촉매 | Iron | HCID 23925 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 5-Bromo-o-toluidine | HCID 2734805 | 102.2% |
반응 단계
A slurry of 5-bromo-2-methylnitrobenzene (3.00 g), iron powder (3.11 g), and ammonium chloride (2.97 g), in 3:1 ethanol : water (50 ml) was heated at reflux temperature for 1 hour. The mixture was poured into 10% aqueous sodium hydroxide and filtered through Celite®. The filtrate was then extracted with ethyl acetate, the extracts washed with brine, dried over magnesium sulfate, filtered and evaporated to afford the subtitle compound as an oil (2.64 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06300352B1 |
| 출처 데이터셋 | uspto-grants-2001_10 |
| ORD ID | ord-0afe2c257b8f4b8fba79f5c0eb0868fb |
| 출처 메모 | uspto-grants-2001_10 |