Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 1-[(4,5-Diphenyloxazol-2-yl)methylamino]-1,2,3,4-tetrahydro-5-methoxynaphthalene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 5-Methoxy-1,2,3,4-tetrahydronaphthalen-1-amine | HCID 38899 | — |
| 반응물 | 2-Bromomethyl-4,5-diphenyl-oxazole | HCID 568599 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-[(4,5-Diphenyloxazol-2-yl)methylamino]-1,2,3,4-tetrahydro-5-methoxynaphthalene | HCID 18367394 | 76.5% |
반응 단계
A solution of 1,2,3,4-tetrahydro-5-methoxy-1-naphthalenamine (0.34 g), (4,5-diphenyloxazol-2-yl)methyl bromide (0.50 g) and potassium carbonate (0.60 g) in DMF (7 ml) was stirred for 5 hours at room temperature. The mixture was partitioned between ethyl acetate and water. The organic layer was washed with brine. The dried solvent was evaporated in vacuo. The residue was purified by chromatography on silica gel to give 1-[(4,5-diphenyloxazol-2-yl)methylamino]-1,2,3,4-tetrahydro-5-methoxynaphthalene (0.50 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06300344B1 |
| 출처 데이터셋 | uspto-grants-2001_10 |
| ORD ID | ord-4e86e2e5d5f74d80b335f378c6f4041d |
| 출처 메모 | uspto-grants-2001_10 |