8-bromo-2-((tert-butoxycarbonyl)amino)-3H-benzo[b]azepine-4-carboxylic acid → tert-butyl (1E,4E)-8-bromo-4-((3-(tert-butyldimethylsilyloxy)propyl)(propyl)carbamoyl)-3H-benzo[b]azepin-2-ylcarbamate

HRID 38019

반응식

HRID 38019 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2=[C:6]([CH:23]=1)[N:7]=[C:8]([NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:9][C:10]([C:12]([OH:14])=O)=[CH:11]2.[Si:24]([O:31][CH2:32][CH2:33][CH2:34][NH:35][CH2:36][CH2:37][CH3:38])([C:27]([CH3:30])([CH3:29])[CH3:28])([CH3:26])[CH3:25]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2=[C:6]([CH:23]=1)[N:7]=[C:8]([NH:15][C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:22])[CH3:21])[CH2:9][C:10]([C:12](=[O:14])[N:35]([CH2:34][CH2:33][CH2:32][O:31][Si:24]([C:27]([CH3:28])([CH3:30])[CH3:29])([CH3:26])[CH3:25])[CH2:36][CH2:37][CH3:38])=[CH:11]2

참가 물질

3

반응물 2

HCID 669596238-bromo-2-((tert-butoxycarbonyl)amino)-3H-benzo[b]azepine-4-carboxylic acidHCID 866534723-(tert-butyldimethylsilyloxy)-N-propylpropan-1-amine

생성물 1

HCID 86652684tert-butyl (1E,4E)-8-bromo-4-((3-(tert-butyldimethylsilyloxy)propyl)(propyl)carbamoyl)-3H-benzo[b]azepin-2-ylcarbamate

실험 절차

The title compound was prepared by the procedure as described in Example 101 (Step H) using (1E,4E)-8-bromo-2-(tert-butoxycarbonylamino)-3H-benzo[b]azepine-4-carboxylic acid and 3-(tert-butyldimethylsilyloxy)-N-propylpropan-1-amine. MS APCI (+) m/z 594, 596 (M+1, Br pattern) detected.

출처 및 근거

ORD 기록
ord-d3063404fdce45e0b52aa0425b58f71f
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524702B2

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