Water → 7-Chloro-2H-thieno[2,3-f][1,3]benzodioxole-6-carboxylic acid

HRID 380239노트

반응식

HRID 380239 반응식
[OH2:1].[Cl:2][C:3]1[C:4]2[CH:14]=[C:13]3[O:15][CH2:16][O:17][C:12]3=[CH:11][C:5]=2[S:6][C:7]=1[C:8](Cl)=[O:9]>O1CCOCC1>[Cl:2][C:3]1[C:4]2[CH:14]=[C:13]3[O:15][CH2:16][O:17][C:12]3=[CH:11][C:5]=2[S:6][C:7]=1[C:8]([OH:1])=[O:9]

참가 물질

4

반응물 2

HCID 962WaterHCID 27576813-Chloro-5,6-methylenedioxybenzothiophene-2-carbonyl chloride

생성물 1

HCID 183643997-Chloro-2H-thieno[2,3-f][1,3]benzodioxole-6-carboxylic acid

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

40 ml of water are added to a solution of 70 mmol of the compound of Step A in 250 ml of dioxane. After 20 hours' reflux and then return to ambient temperature, a precipitate forms. After filtration and rinsing with water until neutral, the precipitate is dried over P2O5 under reduced pressure, allowing the expecting product to be isolated.

후처리

  1. temperatureAfter 20 hours' reflux
  2. customreturn to ambient temperature
  3. filtrationAfter filtration
  4. washrinsing with water until neutral, the precipitate
  5. dry with materialis dried over P2O5 under reduced pressure
  6. customto be isolated

출처 및 근거

ORD 기록
ord-7f547cf8cb824ce4b1eb138bd2bd2e6d
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06302837B1

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