Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trimethylsilylacetylene → 4-Ethynyl-4'-propylbicyclohexyl-4-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trimethylsilylacetylene | HCID 66111 | — |
| 반응물 | [1,1'-Bicyclohexyl]-4-one,4'-propyl-, | HCID 4354185 | — |
| 반응물 | Tetrabutylammonium Fluoride Trihydrate | HCID 11726816 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-Ethynyl-4'-propylbicyclohexyl-4-ol | HCID 18364504 | — |
반응 단계
24.32 ml of (trimethylsilyl)acetylene are added dropwise at −30° C. to a solution of 30.0 g of 4′-propylbicyclohexyl-4-one and 3.41 g of tetrabutylammonium fluoride trihydrate in 300 ml of THF. The cooling bath is removed after 5 minutes, and the reaction mixture is stirred at RT for 2 hours. A suspension of 39.2 g of potassium fluoride in methanol is subsequently added, and the mixture is stirred at RT for 3 days. Conventional work-up gives 4-ethynyl-4′-propylbicyclohexyl-4-ol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06303194B1 |
| 출처 데이터셋 | uspto-grants-2001_10 |
| ORD ID | ord-7c791d3d5c9643b3b52af18291260b8a |
| 출처 메모 | uspto-grants-2001_10 |