Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Lawesson's reagent → 3-Amino-2-thiophenecarbothioamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Lawesson's reagent | HCID 87949 | — |
| 반응물 | 3-Aminothiophene-2-carboxamide | HCID 518993 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-Amino-2-thiophenecarbothioamide | HCID 14321102 | 57.1% |
반응 단계
A solution of 3-aminothiophene-2-carboxamide (4.5 g, 31 mmol) in tetrahydrofuran was treated with Lawesson's Reagent (7.7 g, 190 mmol) and the solution was stirred at room temperature for 18 h. The solvent was removed and the residue purified by chromatography on silica gel using dichloromethane as eluent. The product was obtained as a yellow powder (2.8 g, 56%), m.p. 98-99° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06303613B1 |
| 출처 데이터셋 | uspto-grants-2001_10 |
| ORD ID | ord-b8dbf243a8a842919d2cafadcf065e20 |
| 출처 메모 | uspto-grants-2001_10 |