1-Benzyl-4-hydroxy-4-(6-methoxynaphth-2-yl)piperidine → 4-Hydroxy-4-(6-methoxynaphth-2-yl)-piperidine

HRID 380545노트

반응식

HRID 380545 반응식
C([N:8]1[CH2:13][CH2:12][C:11]([OH:26])([C:14]2[CH:23]=[CH:22][C:21]3[C:16](=[CH:17][CH:18]=[C:19]([O:24][CH3:25])[CH:20]=3)[CH:15]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>[Pd].CO>[OH:26][C:11]1([C:14]2[CH:23]=[CH:22][C:21]3[C:16](=[CH:17][CH:18]=[C:19]([O:24][CH3:25])[CH:20]=3)[CH:15]=2)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

참가 물질

5

반응물 2

HCID 183652491-Benzyl-4-hydroxy-4-(6-methoxynaphth-2-yl)piperidineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 183652414-Hydroxy-4-(6-methoxynaphth-2-yl)-piperidine수율 86%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 1.0 gm (2.9 mMol) 1-benzyl-4-hydroxy-4-(6-methoxynaphth-2-yl)piperidine and 5% palladium on carbon in 20 mL methanol was stirred at room temperature under about 1 atmosphere of hydrogen for 6 hours. The reaction mixture was filtered through a bed of CELITE and the filtrate was concentrated under reduced pressure to provide 0.64 gm (86%) of the desired compound as a white foam. A portion of the material was converted to the oxalate salt for analysis.

후처리

  1. filtrationThe reaction mixture was filtered through a bed of CELITE
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-2e31b536f79245f2b56f295a7b2b46bf
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06303627B1

반응 노트

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