Benzothiazole → 6-Nitrobenzothiazole

반응식

[N+:1]([O-:4])(O)=[O:2].OS(O)(=O)=O.[S:10]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]=[CH:11]1>>[N+:1]([C:16]1[CH:17]=[CH:18][C:13]2[N:12]=[CH:11][S:10][C:14]=2[CH:15]=1)([O-:4])=[O:2]

참가 물질

반응물 2

HCID 7222Benzothiazole

HCID 71777668Sulfuric acid, mixt. with nitric acid

생성물 1

HCID 762566-Nitrobenzothiazole수율 79%

반응 조건

온도: 25 °C

실험 절차

To a 30 mL solution of 1:1 mixture of HNO3—H2SO4 was added benzothiazole (7.0 mL, 53 mmol) slowly over 1 h period at −25° C. and resulting solution was stirred for 12 h. Reaction temperature was allowed to warm up to 25° C. The reaction mixture was poured into ice water to produce a yellow precipitation which was subjected to column chromatography (CHCl3, neat) to yield 7.3 g (41 mmol, 79%) of the desired product.

후처리

customresulting solution
customReaction temperature
customto produce
customa yellow precipitation which

출처 및 근거

ORD 기록: ord-047e4bab03954aa0a78ab5ebb53f5f2e
출처 데이터셋: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06303643B1

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