Trifluoroacetic acid → 1-(2-amino-3-(1H-indol-3-yl)propionyl)-4-benzylpiperidine-4-carboxylic acid N',N'-dimethylhydrazide

HRID 380663노트

반응식

HRID 380663 반응식
C(OC(=O)[NH:7][CH:8]([CH2:30][C:31]1[C:39]2[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=2)[NH:33][CH:32]=1)[C:9]([N:11]1[CH2:16][CH2:15][C:14]([CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)([C:17]([NH:19][N:20]([CH3:22])[CH3:21])=[O:18])[CH2:13][CH2:12]1)=[O:10])(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:22][N:20]([CH3:21])[NH:19][C:17]([C:14]1([CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:13][CH2:12][N:11]([C:9](=[O:10])[CH:8]([NH2:7])[CH2:30][C:31]2[C:39]3[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=3)[NH:33][CH:32]=2)[CH2:16][CH2:15]1)=[O:18]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 20694720(2-(4-benzyl-4-(N',N'-dimethylhydrazinocarbonyl)piperidine-1-yl)-1-(1H-indole-3-ylmethyl)-2-oxoethyl)carbamic acid tert-butyl ester

생성물 1

HCID 206947011-(2-amino-3-(1H-indol-3-yl)propionyl)-4-benzylpiperidine-4-carboxylic acid N',N'-dimethylhydrazide수율 192.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of (2-(4-benzyl-4-(N′,N′-dimethylhydrazinocarbonyl)piperidine-1-yl)-1-(1H-indole-3-ylmethyl)-2-oxoethyl)carbamic acid tert-butyl ester (0.40 g, 0.73 mmol) in methylene chloride (3 ml) at 0° C. was added trifluoroacetic acid (3 ml) and the mixture was stirred for 30 min. The mixture was quenched with ethanol (20 ml), concentrated in vacuo and stripped three times with methylene chloride to give 0.63 g of 1-(2-amino-3-(1H-indol-3-yl)propionyl)-4-benzylpiperidine-4-carboxylic acid N′,N′-dimethylhydrazide as a colorless oil.

후처리

  1. customThe mixture was quenched with ethanol (20 ml)
  2. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-1f16fab6ced24b3fb1d3a05ec21c993a
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06303620B1

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