Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethyl Sulfoxide → 1-(4-Methylbenzyl)-4-(3-chloropropyl)piperazine dihydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethyl Sulfoxide | HCID 679 | — |
| 반응물 | 1-Bromo-3-chloropropane | HCID 8006 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 1-(4-Methylbenzyl)piperazine | HCID 764723 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 1-(4-Methylbenzyl)-4-(3-chloropropyl)piperazine dihydrochloride | HCID 20153192 | 274.5% |
반응 단계
A mixture of 14.0 g of 1-(4-methylbenzyl)piperazine, 8.0 g of potassium hydroxide and 125 ml of dimethyl sulfoxide was stirred for 45 minutes. 11.8 g of 1-bromo-3-chloropropane were then added, and the mixture was stirred for an additional hour. Water was added, and the product was extracted with ether, and the extract was dried (sodium sulfate) and treated with ethereal hydrochloric acid to give 23.3 g (94% of theory) of 1-(4-methylbenzyl)-4-(3-chloropropyl)piperazine dihydrochloride as a white crystalline solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04722926 |
| 출처 데이터셋 | uspto-grants-1988_02 |
| ORD ID | ord-077a49be5a59401b8abfc287ca092333 |
| 출처 메모 | uspto-grants-1988_02 |