Methanol → 8-Ethyl-6-ethynyl-2,2,4,4-tetramethylchroman
반응식
[CH2:1]([C:3]1[CH:4]=[C:5]([C:17]#[C:18][Si](C)(C)C)[CH:6]=[C:7]2[C:12]=1[O:11][C:10]([CH3:14])([CH3:13])[CH2:9][C:8]2([CH3:16])[CH3:15])[CH3:2].CO.C(=O)([O-])[O-].[K+].[K+].C(OCC)(=O)C>CCCCCC>[CH2:1]([C:3]1[CH:4]=[C:5]([C:17]#[CH:18])[CH:6]=[C:7]2[C:12]=1[O:11][C:10]([CH3:13])([CH3:14])[CH2:9][C:8]2([CH3:16])[CH3:15])[CH3:2]참가 물질
6
실험 절차
Following general procedure E and using 8-ethyl-6-trimethylsilanylethynyl-2,2,4,4-tetramethyl chroman (Intermediate 47, 0.137 g, 0.44 mmol), methanol and potassium carbonate (0.1 g, 0.72 mmol) followed by flash column chromatography over silica gel (230-400 mesh) using 5% ethyl acetate in hexane as the eluent, the title compound was obtained as an oil (0.066 g, 62%).
출처 및 근거
- ORD 기록
- ord-c4f1b4f5a10f462a82a81cb856387655
- 출처 데이터셋
- uspto-grants-2001_10
- 특허 번호
- US06303785B1
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