Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 3-[4-(4-Chlorobenzyl)-2,5-dimethylpiperazin-1-yl]propanethiol dihydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Thiourea | HCID 2723790 | — |
| 반응물 | 1-(4-Chlorobenzyl)-2,5-dimethyl-4-(3-chloropropyl)piperazine | HCID 20153190 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3-[4-(4-Chlorobenzyl)-2,5-dimethylpiperazin-1-yl]propanethiol dihydrochloride | HCID 20153172 | 249.9% |
반응 단계
The procedure described in Example 1(b) was followed, using 12.7 g of thiourea and 26.0 g of 1-(4-chlorobenzyl)-2,5-dimethyl-4-(3-chloropropyl)piperazine in 250 ml of reagent ethanol. The hydrolysis was effected with 10.0 g of sodium hydroxide in 50 ml of water. Work-up, as described above, gave 26.5 g (83% of theory) of 3-[4-(4-chlorobenzyl)-2,5-dimethylpiperazin-1-yl]propanethiol dihydrochloride as a white crystalline solid, M.p. 168°-171° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04722926 |
| 출처 데이터셋 | uspto-grants-1988_02 |
| ORD ID | ord-ac25165bc3e44b80977c05d9becefbc7 |
| 출처 메모 | uspto-grants-1988_02 |