Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Tert-butyl(trans)-2-(1,1'-biphenyl-4-yl)cyclopropylcarbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Boronic Acid | HCID 61668 | — |
| 반응물 | tert-butyl ((1R,2S)-2-(4-bromophenyl)cyclopropyl)carbamate | HCID 86658779 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Acetonitrile--water (1/1) | HCID 18373917 | — |
| 생성물 | Tert-butyl(trans)-2-(1,1'-biphenyl-4-yl)cyclopropylcarbamate | HCID 86658778 | — |
반응 단계
A solution of tert-butyl(trans)-2-(4-bromophenyl)cyclopropylcarbamate (Intermediate F; 1 equiv), 1.2 equiv of the boronic acid, 3.0 equiv of K2CO3 in CH3CN+H2O (4:1) was degassed for 30 mins with Argon gas, added 0.01 equiv of Pd (PPh3)4, heated the reaction mixture at reflux temp for 4 h. The progress of the reaction was monitored by TLC, after completion, poured the reaction mixture into water, extracted with EtOAc. The combined extracts were washed with water, brine, dried over anhydrous Na2SO4, filtered and evaporated. The crude residue was purified by column chromatography to get tert-butyl(trans)-2-(1,1′-biphenyl-4-yl)cyclopropylcarbamate derivative
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524717B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-40bdd2650dc84da68d73597eb7e292c0 |
| 출처 메모 | uspto-grants-2013_09 |