Water → 2-(2-Phenyl-benzyl) adipic acid diethylester

HRID 381238

반응식

HRID 381238 반응식
O.[CH2:2]([O:4][C:5](=[O:15])[CH2:6][CH2:7][CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH3:3].CC[O-].[Na+].[C:20]1([C:26]2[CH:33]=[CH:32][CH:31]=[CH:30][C:27]=2[CH2:28]Br)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C1COCC1>[CH2:2]([O:4][C:5](=[O:15])[CH:6]([CH2:28][C:27]1[CH:30]=[CH:31][CH:32]=[CH:33][C:26]=1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:7][CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH3:3]

참가 물질

6

반응물 4

HCID 962WaterHCID 8844Diethyl AdipateHCID 2633651-(Bromomethyl)-2-phenylbenzeneHCID 2723922Sodium ethoxide

생성물 1

HCID 159139682-(2-Phenyl-benzyl) adipic acid diethylester수율 92%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
60 °C

실험 절차

Into a 3 neck flask, equipped with water cooler, were added 43.8 mL (0.22 mol) of diethyladipate and 220 mL THF. 16.3 g (0.24 mol, 1.1 equivalents) of NaOEt were added in small portions, at 20° C., and the reaction mixture was stirred at 60° C. for 16 hours. After cooling to 20° C., 48.6 g (0.20 mol) of 2-phenyl-benzyl bromide was added dropwise. The reaction mixture was stirred at 60° C., for 16 hours, to give 2-(2-phenyl-benzyl) adipic acid diethylester as a viscous oil, in a yield of 92%.

후처리

  1. temperatureAfter cooling to 20° C.
  2. stirringThe reaction mixture was stirred at 60° C., for 16 hours

출처 및 근거

ORD 기록
ord-332db244a6984dc390f1abd5a2fc578b
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06306791B2

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