Nitric Acid → 2-Iodo-5-nitrobenzoic acid

HRID 381289

반응식

HRID 381289 반응식
[I:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[N+:11]([O-])([OH:13])=[O:12]>S(=O)(=O)(O)O>[I:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 69412-Iodobenzoic acid

생성물 1

HCID 38487452-Iodo-5-nitrobenzoic acid

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

반응 조건

온도
80 °C

실험 절차

2-Iodobenzoic acid (100 g) was dissolved in 400 mL of concentrated sulphuric acid and placed in a 2 liter 3 necked flask. The flask was fitted with reflux condenser, a thermometer and an addition funnel. Fuming nitric acid (400 ml) was added drop by drop. The addition was adjusted in such a way that the temperature was allowed to raise to 80° C. over a period of 2 hours. During the addition, the reaction mixture was stirred vigorously and maintained the temperature at 80° C. for an additional 2 hours. After the completion of the reaction, the reaction mixture was poured slowly into crushed ice (3 Kg). The contents were allowed to settle and were filtered. The yellow precipitate was collected and dried at 30° C. The yield was 90 grams.

후처리

  1. customThe flask was fitted
  2. temperaturewith reflux condenser
  3. additionThe addition
  4. additionDuring the addition
  5. temperaturemaintained the temperature at 80° C. for an additional 2 hours
  6. customAfter the completion of the reaction
  7. additionthe reaction mixture was poured slowly
  8. filtrationwere filtered
  9. customThe yellow precipitate was collected
  10. customdried at 30° C

출처 및 근거

ORD 기록
ord-aa26efb129544d54a21061960d2ba5b5
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06306871B1

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