Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butanol → Tert-butyl 4-methyl-3-nitrobenzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butanol | HCID 6386 | — |
| 반응물 | 4-Methyl-3-nitrobenzoic acid | HCID 7319 | — |
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Tert-butyl 4-methyl-3-nitrobenzoate | HCID 22451886 | 99.2% |
반응 단계
To a solution of 3-nitro-4-methylbenzoic acid (17.3 g 96 mmol) in dichloromethane (250 ml) and tert-butanol (35.8 g 470 mmol) at 0° C. under nitrogen was added 4-dimethylaminopyridine (6 g 50 mmol) and 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (25.8 g 140 mmol) and the solution allowed to come to room temperature over 1 hour. then stirred overnight. The solution was poured into 1:1 ethyl acetate:water (800 ml) and the organic layer washed with aqueous bicarbonate and saturated aqueous sodium chloride. then dried (MgSO4) and evaporated. to give the product as a clear oil (22.6 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06306852B1 |
| 출처 데이터셋 | uspto-grants-2001_10 |
| ORD ID | ord-5954dda2b21e4891a6aa88f0d3e45ef0 |
| 출처 메모 | uspto-grants-2001_10 |