Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Oxalyl chloride → 5-Chlorothiophene-2-carbonyl Chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Oxalyl chloride | HCID 65578 | — |
| 반응물 | 5-Chloro-2-thiophenecarboxylic acid | HCID 95048 | — |
| 촉매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 5-Chlorothiophene-2-carbonyl Chloride | HCID 589223 | — |
반응 단계
To a chilled solution of 5-chlorothiophene-2-carboxylic acid (0.16 g, 1.0 mmol) in EtOAc (3 mL) and DMF (1 drop) was added neat oxalyl chloride (92 μL, 1.05 mmol). The reaction mixture was stirred cold for 2 hr and concentrated in vacuo to give crude 5-chlorothiophene-2-carbonyl chloride.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524721B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-f3ab523db84d4747a39bf21f2f7e9033 |
| 출처 메모 | uspto-grants-2013_09 |