Pentafluoropyridine → 2,3,5,6-Tetrafluoro-4-methoxypyridine

반응식

[F:1][C:2]1[N:7]=[C:6]([F:8])[C:5]([F:9])=[C:4](F)[C:3]=1[F:11].[CH3:12][O-:13].[Na+]>>[CH3:12][O:13][C:4]1[C:3]([F:11])=[C:2]([F:1])[N:7]=[C:6]([F:8])[C:5]=1[F:9]

참가 물질

반응물 2

HCID 69690Pentafluoropyridine

HCID 10942334Sodium Methoxide

생성물 1

HCID 139996172,3,5,6-Tetrafluoro-4-methoxypyridine

실험 절차

To pentafluoropyridine (1.0 g, 5.9 mmol) in petroleum ether (60 mL) at 0° C. was added sodium methoxide (0.32 mg, 5.9 mmol). After stirring for 12 hours at ambient temperature, the reaction was washed with water, dried (MgSO4), and the solvent was removed in vacuo to give 4-methoxy-2,3,5,6-tetrafluoropyridine; NMR (CDCl3) 4.3 ppm.

후처리

washthe reaction was washed with water
dry with materialdried (MgSO4)
customthe solvent was removed in vacuo

출처 및 근거

ORD 기록: ord-615eff473bbf4d638f832f9423b112e5
출처 데이터셋: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06306884B1

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