참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | p-Aminocinnamic acid | HCID 1549514 | — |
| 반응물 | Potassio isocyanate | HCID 11051572 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | (E)-3-(4-Ureidophenyl)acrylic acid | HCID 18363098 | 80% |
반응 단계
A stirred solution of (E)-3-(4-aminophenyl)acrylic acid (1.0 g, 5.0 mmol) and potassium isocyanate (2.0 g, 5 equiv.) in a mixture of water and acetic acid (50 mL) was heated at 100° C. for 12 hours. After cooling, a white solid precipitated out. Filtration, washing of the filter cake with a mixture of water and MeOH, and drying it in vacuo gave the title compound (0.82 g, 80%) as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06306870B1 |
|---|
| 출처 데이터셋 | uspto-grants-2001_10 |
|---|
| ORD ID | ord-e42b2324aa1745b0b1fc7aada8631e35 |
|---|
| 출처 메모 | uspto-grants-2001_10 |
|---|
