(4-Chloro-3-methoxyphenyl)methanol → 4-Chloro-3-methoxybenzaldehyde
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][OH:9])=[CH:4][C:3]=1[O:10][CH3:11]>C1C=CC=CC=1.O=[Mn]=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[O:9])=[CH:4][C:3]=1[O:10][CH3:11]참가 물질
4
실험 절차
To a solution of (4-chloro-3-methoxyphenyl)methan-1-ol (5.08 g, 29.4 mmol) in benzene (120 mL) was added MnO2 (5.65 g, 65 mmol). The reaction mixture was refluxed for 17 hr, chilled, and filtered through Celite, washing the cake with CH2Cl2 (300 mL). The filtrate was concentrated in vacuo to give 4-chloro-3-methoxybenzaldehyde (4.5 g, 89%).
후처리
- temperatureThe reaction mixture was refluxed for 17 hr
- temperaturechilled
- filtrationfiltered through Celite
- washwashing the cake with CH2Cl2 (300 mL)
- concentrationThe filtrate was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-f074e120e9b04d9f9e37f175fd9d00c9
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08524721B2
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