Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethylene Glycol → Simvastatin
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethylene Glycol | HCID 174 | — |
| 반응물 | 1,3-Propanediol | HCID 10442 | — |
| 반응물 | Neopentyl glycol | HCID 31344 | — |
| 반응물 | HCID 178445512 | HCID 178445512 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Simvastatin | HCID 54454 | — |
반응 단계
Simvastatin boronate (III) is heated in the presence of a suitable diol solvent selected from ethylene glycol, 1,3-propanediol, or neopentyl glycol, under thermal conditions. The product is isolated by concentration of the reaction mixture, dilution with water, and extraction with an organic solvent. The organic solvent is concentrated to a minimum volume and simvastatin is isolated by the addition of a cosolvent and filtration.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06307066B1 |
| 출처 데이터셋 | uspto-grants-2001_10 |
| ORD ID | ord-668282ea8a434ec39afca7f89dc75d3b |
| 출처 메모 | uspto-grants-2001_10 |