4-Toluenesulfonyl chloride → (R)-1-Benzyl-3-pyrrolidinol tosylate

HRID 381735

반응식

HRID 381735 반응식
[CH2:1]([N:8]1[CH2:12][CH2:11][C@@H:10]([OH:13])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:14]1([CH3:24])[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[CH:16][CH:15]=1>O>[CH2:1]([N:8]1[CH2:12][CH2:11][C@@H:10]([OH:13])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1.[S:20]([C:17]1[CH:18]=[CH:19][C:14]([CH3:24])=[CH:15][CH:16]=1)([O-:13])(=[O:22])=[O:21]

참가 물질

4

반응물 2

HCID 73974-Toluenesulfonyl chlorideHCID 643472(R)-(+)-1-Benzyl-3-pyrrolidinol

생성물 1

HCID 86583595(R)-1-Benzyl-3-pyrrolidinol tosylate수율 175.6%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a stirred solution of (R)1-benzyl-3-pyrrolidinol (1.77 g, 10 mmol) pyridine(30 ml) was added p-toluenesulfonyl chloride (9.53 g, 50 mmol) by portions at 0° C. After 90 h stirring at room temperature, water was added to the reaction mixture and the mixture was extracted with ether (150 ml). The extract was washed with water brine, dried (Na2SO4), and concentrated to give 3.06 g (92%) of brown oil.

후처리

  1. extractionthe mixture was extracted with ether (150 ml)
  2. washThe extract was washed with water brine
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-83b8f201dfb748bdafa93b0432845b9a
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06307061B2

연결된 노트

불러오는 중…