Methyl 4-methylaminobenzoate → HCID 20640607, 화합물

HRID 381746

반응식

HRID 381746 반응식
ClC1C=C([C@@H](N2CC[C@H](OCOC)C2)CO)C=CC=1.[Cl:20][C:21]1[CH:22]=[C:23]([C@H:27](O)[CH2:28][N:29]2[CH2:33][CH2:32][C@H:31]([O:34][CH2:35][O:36][CH3:37])[CH2:30]2)[CH:24]=[CH:25][CH:26]=1.[CH3:39][NH:40][C:41]1[CH:50]=[CH:49][C:44]([C:45]([O:47][CH3:48])=[O:46])=[CH:43][CH:42]=1>>[Cl:20][C:21]1[CH:22]=[C:23]([C@H:27]([N:40]([C:41]2[CH:50]=[CH:49][C:44]([C:45]([O:47][CH3:48])=[O:46])=[CH:43][CH:42]=2)[CH3:39])[CH2:28][N:29]2[CH2:33][CH2:32][C@H:31]([O:34][CH2:35][O:36][CH3:37])[CH2:30]2)[CH:24]=[CH:25][CH:26]=1

참가 물질

4

반응물 3

HCID 140375Methyl 4-methylaminobenzoateHCID 20640582HCID 20640582, 화합물HCID 206405862-(R)-(3-chlorophenyl)-2-(3-(S)-methoxymethoxypyrrolidin-1-yl)ethanol

생성물 1

HCID 20640607HCID 20640607, 화합물수율 66%

실험 절차

This was prepared from the mixture of 2-(R)-(3-chlorophenyl)-2-(3-(S)-methoxymethoxypyrrolidin-1-yl)ethanol and 1-(S)-(3-chlorophenyl)-2-(3-(S)-methoxymethoxypyrrolidin-1-yl)ethanol and methyl 4-methylaminobenzoate in 66% yield according to a procedure similar to that described in Example 1 (i).

출처 및 근거

ORD 기록
ord-151e6376e59548ddbb82c8248b6c15d8
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06307061B2

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