참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl 4,4,4-trifluoroacetoacetate | HCID 67793 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Platinum | HCID 23939 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | Ethyl 4,4,4-trifluoro-3-hydroxybutanoate | HCID 136210 | 96% |
반응 단계
Ethyl 4,4,4-trifluoroacetoacetate (50 g), under a blanket of nitrogen gas, is heated to 40° C. and treated with platinum (0.5 g of 1% Pt/C, 0.05% load) and triethylamine (0.2 g, 0.4% load). Hydrogen is charged to a pressure of 5 bars, and the mixture agitated at 40° C. for 6h. After filtration to remove the catalyst, 48.5 g (96% yield) of ethyl 4,4,4-trifluoro-3-hydroxybutyrate is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06307094B1 |
|---|
| 출처 데이터셋 | uspto-grants-2001_10 |
|---|
| ORD ID | ord-b07d5a3524ed43d681a9c5a766d9df0e |
|---|
| 출처 메모 | uspto-grants-2001_10 |
|---|
