Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bromobenzene → Methyl 4-(4-bromophenyl)-4-oxobutanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bromobenzene | HCID 7961 | — |
| 반응물 | Butanoic acid, 4-chloro-4-oxo-, methyl ester | HCID 73888 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Methyl 4-(4-bromophenyl)-4-oxobutanoate | HCID 838865 | — |
반응 단계
In a manner similar to Example 2, Step (a), bromobenzene (10.0 mL, 0.0950 mol) was allowed to react with 3-carbomethoxypropionyl chloride (12.9 mL, 0.105 mol) in the presence of aluminum chloride (26.9 g, 0.0202 mol) in dichloromethane to give, after chromatography on silica gel (435 g, 230-400 mesh), eluting with hexanes-acetone (9:1, 10×400 mL; 8:1, 7×400 mL), 21.2 g of 4-(4-bromo-phenyl)-4-oxo-butyric acid, methyl ester as an off-white solid; mp 49-51° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06307089B2 |
| 출처 데이터셋 | uspto-grants-2001_10 |
| ORD ID | ord-617a969c2e0f473d93ee8180621ea705 |
| 출처 메모 | uspto-grants-2001_10 |