Ammonia → HCID 10184106, 화합물

참여 물질

역할	이름	HCID	투입량
반응물	Ammonia	HCID 222	—
반응물	2-Bromo-5-chlorothiophene	HCID 76133	—
반응물	4-(4-chlorophenyl)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone	HCID 21934129	—
생성물	HCID 10184106	HCID 10184106	—

반응 단계

The title compound was prepared according to Example 93, substituting 4-(4-chlorophenyl)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone in place of 4-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone and substituting 2-bromo-5-chlorothiophene in place of 4-bromothioanisole (yield: 150 mg, 45%). mp 249-251° C. 1H NMR (300 MHz, CDCl3) δ 3.05 (s, 3H), 6.92 (d, J=9 Hz, 1H), 7.18 (d, J=9 Hz, 2H), 7.31 (d, J=9 Hz, 2H), 7.39 (d, J=9 Hz, 2H), 7.58 (d, J=6 Hz, 1H), 7.94 (d, J=9 Hz, 2Hz, 2H), 8.04 (s, 1H). MS (DCI/NH3) m/z 477 (M+H)+, 494 (M+NH4)+. Anal. calc. for C21H14Cl2N2O3S2.H2O: C, 50.9; H, 3.03; N, 5.60. Found: C, 50.5; H, 2.79; N, 5.26.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06307047B1
출처 데이터셋	uspto-grants-2001_10
ORD ID	ord-12dd957c41fa4d8d84f1e26dff3a780c
출처 메모	uspto-grants-2001_10