Aluminum bromide → 4-(4-fluorophenoxy)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone

HRID 381889

반응식

HRID 381889 반응식
C([N:8]1[C:13](=[O:14])[C:12]([O:15][C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)=[C:11]([C:23]2[CH:28]=[CH:27][C:26]([S:29]([CH3:32])(=[O:31])=[O:30])=[CH:25][CH:24]=2)[CH:10]=[N:9]1)C1C=CC=CC=1.[Al](Br)(Br)Br>C1(C)C=CC=CC=1>[F:22][C:19]1[CH:18]=[CH:17][C:16]([O:15][C:12]2[C:13](=[O:14])[NH:8][N:9]=[CH:10][C:11]=2[C:23]2[CH:24]=[CH:25][C:26]([S:29]([CH3:32])(=[O:31])=[O:30])=[CH:27][CH:28]=2)=[CH:21][CH:20]=1

참가 물질

4

반응물 2

HCID 24409Aluminum bromideHCID 98465812-Benzyl-4-(4-fluorophenoxy)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone

생성물 1

HCID 219341624-(4-fluorophenoxy)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

The title compound was prepared by treating 2-benzyl-4-(4-fluorophenoxy)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone (Example 75) with AlBr3 in toluene according to the procedure in Example 11 (yield: 1.8 g, 95%).

출처 및 근거

ORD 기록
ord-4f418014830043bda525eb82ddd335ce
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06307047B1

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