Water → HCID 59971430, 화합물

HRID 382009노트

반응식

HRID 382009 반응식
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][C:5](=[O:11])[NH:6]2.[NH:12]1[CH:16]=[CH:15][CH:14]=[C:13]1[CH:17]=O.O>N1CCCCC1.CC(O)C>[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1/[C:4](=[CH:17]/[C:13]1[NH:12][CH:16]=[CH:15][CH:14]=1)/[C:5](=[O:11])[NH:6]2

참가 물질

6

반응물 3

HCID 962WaterHCID 13854Pyrrole-2-carboxaldehydeHCID 27631904-bromo-2,3-dihydro-1H-indol-2-one

생성물 1

HCID 59971430HCID 59971430, 화합물

시약·촉매·용매 2

HCID 3776Isopropanol용매HCID 8082Piperidine용매

반응 조건

온도
85 °C

실험 절차

A mixture of 4-bromo-1,3-dihydro-2H-indol-2-one (0.2 g, 0.94 mmol) (see Kosuge et al., supra), and excess pyrrole-2-carboxaldehyde (0.11 g, 1.13 mmol) (Aldrich) in 1% piperidine in 2-propanol (2 mL) was heated at 85° C. for 2 h. Hot water (2 mL) was added. On cooling, the crystallized product was filtered off, washed with aqueous 2-propanol and dried. (Yield 0.26 g, 96%).

후처리

  1. temperatureOn cooling
  2. filtrationthe crystallized product was filtered off
  3. washwashed with aqueous 2-propanol
  4. customdried

출처 및 근거

ORD 기록
ord-fb8c200ef8b14006b47ac1d51ac9f564
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06307056B1

반응 노트

불러오는 중…