3-Phenylfuran → 2,5-Dihydro-2,5-dimethoxy-3-phenylfuran

반응식

[C:1]1(C2C=CC=CC=2)[CH:6]=[CH:5][C:4]([C:7]2[CH:8]([O:14][CH3:15])[O:9][CH:10]([O:12][CH3:13])[CH:11]=2)=[CH:3][CH:2]=1.C1(C2C=COC=2)C=CC=CC=1>>[CH3:15][O:14][CH:8]1[C:7]([C:4]2[CH:5]=[CH:6][CH:1]=[CH:2][CH:3]=2)=[CH:11][CH:10]([O:12][CH3:13])[O:9]1

참가 물질

반응물 2

HCID 5188023-Phenylfuran

HCID 183803523-Biphenyl-4-yl-2,5-dihydro-2,5-dimethoxyfuran

생성물 1

HCID 183803672,5-Dihydro-2,5-dimethoxy-3-phenylfuran수율 82%

실험 절차

According to the procedure described in Example 1(a) for the preparation of 3-biphenyl-4-yl-2,5-dihydro-2,5-dimethoxyfuran, 3-phenylfuran (see Pridgen, L. N.; Jones, S. S. J. Org. Chem. 1982, 47, 1590-1592 and Yang, Y.; Wong, H. N. C. Tetrahedron 1994, 32, 9583-9608; 848 mg, 5.89 mmol) provided 1.00 g (82%) of 2,5-dihydro-2,5-dimethoxy-3-phenylfuran as a yellow oil, which was an approximately 80:20 mixture of diastereomers by 1H NMR and used without further purification.

출처 및 근거

ORD 기록: ord-6c95fa0a61fe4f2ea66187116e6a16c9
출처 데이터셋: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06306892B1

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