Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-(2-aminoethyl)acetamide → N-[2-(2-chloro-5-iodopyrimidine-4-ylamino)ethyl]acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-(2-aminoethyl)acetamide | HCID 66082 | — |
| 반응물 | 2,4-Dichloro-5-iodopyrimidine | HCID 263438 | — |
| 생성물 | N-[2-(2-chloro-5-iodopyrimidine-4-ylamino)ethyl]acetamide | HCID 59550867 | 71% |
반응 단계
In analogy to GP 2 reaction of 2,4-dichloro-5-iodopyrimidine (1.0 g, 3.6 mmol) with N-(2-aminoethyl)acetamide (e.g. ABCR, Aldrich) (0.42 mL, 3.9 mmol) provided the desired product in 71% yield (878 mg) after trituration of the crystals obtained with diethyl ether.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524724B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-babe7f6101a14a28b4e9c3ffab25ca6a |
| 출처 메모 | uspto-grants-2013_09 |