Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Bromo-2,4-dichloropyrimidine → 5-Bromo-2-chloro-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Bromo-2,4-dichloropyrimidine | HCID 289973 | — |
| 반응물 | 4-Aminotetrahydropyran | HCID 419223 | — |
| 생성물 | 5-Bromo-2-chloro-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-amine | HCID 59550890 | 83% |
반응 단계
In the reaction of 5-bromo-2,4-dichloropyrimidine (300 mg, 1.32 mmol) with tetrahydropyran-4-ylamine (144 mg, 1.42 mmol) according to GP 2, the desired product is obtained in 83% yield (320 mg) after chromatographic purification (silica gel, ethyl acetate/hexane with ethyl acetate: 0-100%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524724B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-b44b73f37f22475bb61cb295576d7ffe |
| 출처 메모 | uspto-grants-2013_09 |