Methanesulfonyl chloride → N-(3-ethynylphenyl)methanesulfonamide
반응식
[C:1]([C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][CH:9]=1)[NH2:6])#[CH:2].[CH3:10][S:11](Cl)(=[O:13])=[O:12]>N1C=CC=CC=1>[C:1]([C:3]1[CH:4]=[C:5]([NH:6][S:11]([CH3:10])(=[O:13])=[O:12])[CH:7]=[CH:8][CH:9]=1)#[CH:2]참가 물질
4
실험 절차
To a solution of 3-ethynyl aniline (1.05 mL, 10.0 mmol) in pyridine (5 mL) was added methanesulfonyl chloride (857 μL, 1.10 eq.) at a temperature of 0° C. The resulting mixture was stirred overnight at room temperature and was then evaporated. The residue was treated with 2 N aq. HCl (25 mL) and subsequently extracted with ethyl acetate (2×30 mL). The combined organic layers were dried over MgSO4 and evaporated to give the desired methanesulfonamide in quantitative yield. It was used without further purification.
후처리
- customwas then evaporated
- additionThe residue was treated with 2 N aq. HCl (25 mL)
- extractionsubsequently extracted with ethyl acetate (2×30 mL)
- dry with materialThe combined organic layers were dried over MgSO4
- customevaporated
출처 및 근거
- ORD 기록
- ord-e04eb91ca7634a4a97f9b40e63bc61d3
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08524724B2
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