Methanesulfonyl chloride → N-(3-ethynylphenyl)methanesulfonamide

HRID 38225

반응식

HRID 38225 반응식
[C:1]([C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][CH:9]=1)[NH2:6])#[CH:2].[CH3:10][S:11](Cl)(=[O:13])=[O:12]>N1C=CC=CC=1>[C:1]([C:3]1[CH:4]=[C:5]([NH:6][S:11]([CH3:10])(=[O:13])=[O:12])[CH:7]=[CH:8][CH:9]=1)#[CH:2]

참가 물질

4

반응물 2

HCID 31297Methanesulfonyl chlorideHCID 104682Benzenamine, 3-ethynyl-

생성물 1

HCID 57131399N-(3-ethynylphenyl)methanesulfonamide

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a solution of 3-ethynyl aniline (1.05 mL, 10.0 mmol) in pyridine (5 mL) was added methanesulfonyl chloride (857 μL, 1.10 eq.) at a temperature of 0° C. The resulting mixture was stirred overnight at room temperature and was then evaporated. The residue was treated with 2 N aq. HCl (25 mL) and subsequently extracted with ethyl acetate (2×30 mL). The combined organic layers were dried over MgSO4 and evaporated to give the desired methanesulfonamide in quantitative yield. It was used without further purification.

후처리

  1. customwas then evaporated
  2. additionThe residue was treated with 2 N aq. HCl (25 mL)
  3. extractionsubsequently extracted with ethyl acetate (2×30 mL)
  4. dry with materialThe combined organic layers were dried over MgSO4
  5. customevaporated

출처 및 근거

ORD 기록
ord-e04eb91ca7634a4a97f9b40e63bc61d3
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524724B2

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