Sodium Carbonate → 2-(4-((2,4-Dioxothiazolidin-5-YL)methyl)phenoxy)acetic acid

HRID 382290노트

반응식

HRID 382290 반응식
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:21]=[CH:20][C:12]([O:13][CH2:14][C:15]([O:17]CC)=[O:16])=[CH:11][CH:10]=2)[S:3]1.C([O-])([O-])=O.[Na+].[Na+]>CO.O>[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:21]=[CH:20][C:12]([O:13][CH2:14][C:15]([OH:17])=[O:16])=[CH:11][CH:10]=2)[S:3]1

참가 물질

5

반응물 2

HCID 10340Sodium CarbonateHCID 10852377Ethyl 2-[4-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]phenoxy]acetate

생성물 1

HCID 113234852-(4-((2,4-Dioxothiazolidin-5-YL)methyl)phenoxy)acetic acid수율 80%

시약·촉매·용매 2

HCID 887Methanol용매2회HCID 962Water용매

반응 조건

온도
27.5 °C

실험 절차

To a stirred solution of ethyl [4-[[2,4-dioxo-1,3-thiazolidine-5-yl]methyl]phenoxy]acetate (110 g, 0.36 mol) in methanol (0.65 L) was added as solutino of Na2CO3 (200 g, 1.88 mol) in water (0.65 L) and stirred for 5 h at 25 to 30° C. After completion of the reaction, methanol was removed under reduced pressure; water was added to the residue and was acidified with hydrochlori acid. The precipitated while solid was filtered and dired to yield the title compound (80 g, 80%). mp: 181-183° C.

후처리

  1. customwas removed under reduced pressure
  2. additionwater was added to the residue
  3. customThe precipitated while solid
  4. filtrationwas filtered

출처 및 근거

ORD 기록
ord-d707206b019c4f3791cbd1b28facf20a
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06310069B1

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