Triethylamine → HCID 178418566, 화합물

HRID 3823노트

반응식

HRID 3823 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:13]=[C:14]=[O:15])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[ClH:16].Cl.[Cl:18][C:19]1[CH:36]=[CH:35][C:22]([CH2:23][CH2:24][N:25]2[CH2:30][CH2:29][N:28]([CH2:31][CH2:32][CH2:33][SH:34])[CH2:27][CH2:26]2)=[CH:21][CH:20]=1.C(N(CC)CC)C>C(Cl)Cl>[ClH:18].[ClH:16].[CH3:12][O:11][C:7]1[CH:6]=[C:5]([NH:13][C:14](=[SH:34][CH2:33][CH2:32][CH2:31][N:28]2[CH2:29][CH2:30][N:25]([CH2:24][CH2:23][C:22]3[CH:21]=[CH:20][C:19]([Cl:18])=[CH:36][CH:35]=3)[CH2:26][CH2:27]2)[OH:15])[CH:4]=[C:3]([O:2][CH3:1])[C:8]=1[O:9][CH3:10]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 5177665-Isocyanato-1,2,3-trimethoxybenzeneHCID 137311263-[4-(4-Chlorophenethyl)piperazin-1-yl]propanethiol dihydrochloride

생성물 1

HCID 178418566HCID 178418566, 화합물수율 46.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The procedure described in Example 2 was followed, using 2.5 g of 3,4,5-trimethoxyphenyl isocyanate, 4.4 g of 3-[4-(4-chlorophenethyl)piperazin-1-yl]propanethiol dihydrochloride, 1.2 g of triethylamine and 50 ml of methylene chloride, to give 1.6 g (23% of theory) of N-(3,4,5-trimethoxyphenyl)-S-{3-[4-(4-chlorophenethyl)piperazin-1-yl]propyl}thiocarbamate dihydrochloride as a white crystalline solid, M.p. 239°-241° C.

출처 및 근거

ORD 기록
ord-a578f973ce364f93924ecc2ae775a857
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04722926

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