Azido(trimethyl)stannane → Hypoxanthine

HRID 382432노트

반응식

HRID 382432 반응식
C(C1C=CC=CC=1C1C=CC(C[N:14]2[C:18]([C:19]([NH2:21])=[O:20])=[C:17]([NH:22][C:23](=O)CC)[N:16]=[CH:15]2)=CC=1)#N.C[Sn](N=[N+]=[N-])(C)C>C1(C)C=CC=CC=1>[NH:21]1[C:19](=[O:20])[C:18]2[NH:14][CH:15]=[N:16][C:17]=2[N:22]=[CH:23]1

참가 물질

4

반응물 2

HCID 5104973Azido(trimethyl)stannaneHCID 183601781-(4-(2-Cyanophenyl)benzyl)-4-propanoylamino-5-imidazole carboxamide

생성물 1

HCID 135398638Hypoxanthine수율 83%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

2.17 g (5.81 mmol) of the amide thus prepared was suspended in 30 ml of toluene and 5.00 g (24.3 mmol) of trimethyl tin azide was added to the suspension, followed by heating for 23 hours while refluxing. Crystals produced was separated by filtration and dissolved in methanol containing 1N hydrochloric acid. The solution was neutralized with 4 N sodium hydroxide aqueous solution. After evaporating methanol, crystals collected by filtration was purified by suspending them in hot methanol, thereby obtaining 1.93 g of 2-ethyl-7-(4-2-tetrazolylphenyl)benzyl)hypoxanthine (yield 83%).

후처리

  1. temperatureby heating for 23 hours
  2. temperaturewhile refluxing
  3. customCrystals produced
  4. customwas separated by filtration
  5. dissolutiondissolved in methanol containing 1N hydrochloric acid
  6. customAfter evaporating methanol, crystals
  7. filtrationcollected by filtration
  8. customwas purified

출처 및 근거

ORD 기록
ord-2bc02e0a4b2e4d52a01374bbb12c7810
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06310070B1

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