4-Amino-1-(4-t-butylbenzyl)-5-imidazolecarboxamide → 1-(4-t-butylbenzyl)-4-(3-(N-t-butyloxycarbonyl-N-methylamino)benzoylamino)-5-imidazolecarboxamide

HRID 382433

반응식

HRID 382433 반응식
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([CH3:20])([CH3:19])[CH3:18])=[CH:13][CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[C:21]([O:25][C:26]([N:28]([C:30]1[CH:31]=[C:32]([CH:36]=[CH:37][CH:38]=1)[C:33](O)=[O:34])[CH3:29])=[O:27])([CH3:24])([CH3:23])[CH3:22]>>[C:17]([C:14]1[CH:15]=[CH:16][C:11]([CH2:10][N:5]2[C:6]([C:7]([NH2:9])=[O:8])=[C:2]([NH:1][C:33](=[O:34])[C:32]3[CH:36]=[CH:37][CH:38]=[C:30]([N:28]([C:26]([O:25][C:21]([CH3:23])([CH3:22])[CH3:24])=[O:27])[CH3:29])[CH:31]=3)[N:3]=[CH:4]2)=[CH:12][CH:13]=1)([CH3:20])([CH3:19])[CH3:18]

참가 물질

3

반응물 2

HCID 183602894-Amino-1-(4-t-butylbenzyl)-5-imidazolecarboxamideHCID 223491653-(N-Boc-N-methylamino)benzoic acid

생성물 1

HCID 183602021-(4-t-butylbenzyl)-4-(3-(N-t-butyloxycarbonyl-N-methylamino)benzoylamino)-5-imidazolecarboxamide수율 65%

실험 절차

An amidation reaction and post-treatment were carried out under the same conditions as in Example 17, using 4.31 g (14.0 mmol) of 4-amino-1-(4-t-butylbenzyl)-5-imidazolecarboxamide which was prepared in the same manner as in Example 57 and 3-(N-t-butyloxycarbonyl-N-methylamino)benzoic acid instead of 3-pyridylacetic acid hydrochloride to obtain 4.59 g of 1-(4-t-butylbenzyl)-4-(3-(N-t-butyloxycarbonyl-N-methylamino)benzoylamino)-5-imidazolecarboxamide (yield 65%).

후처리

  1. customAn amidation reaction

출처 및 근거

ORD 기록
ord-bebdffeef9b84c0ebfe86286763d7473
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06310070B1

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