Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → (E)-1-(4-Methylpyrid-2-yl)-2-styryl-1H-benzimidazole hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 2-(2-Phenylethenyl)-1h-benzimidazole | HCID 242965 | — |
| 반응물 | 2-Fluoro-4-methylpyridine | HCID 2737403 | — |
| 반응물 | (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole | HCID 9796241 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (E)-1-(4-Methylpyrid-2-yl)-2-styryl-1H-benzimidazole hydrochloride | HCID 22736699 | — |
반응 단계
Free base of the titled compound was prepared from 2-styryl-1H-benzimidazole and 2-fluoro-4-methylpyridine according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method B). The free base was treated with a 10% methanol solution of hydrogen chloride and concentrated to dryness. The residue was recrystallized from ethyl acetate/n-hexane to give the titled compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06310079B1 |
| 출처 데이터셋 | uspto-grants-2001_10 |
| ORD ID | ord-b6bc70bd70dd453893ec6ad11ec32443 |
| 출처 메모 | uspto-grants-2001_10 |