Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Oxalic Acid → (E)-3,4-Dimethoxystyryl-1-(2-pyridyl)-1H-benzimidazole oxalate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Oxalic Acid | HCID 971 | — |
| 반응물 | N1-(pyridin-2-yl)benzene-1,2-diamine | HCID 752150 | — |
| 반응물 | (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole | HCID 9796241 | — |
| 반응물 | 3,4-Dimethoxycinnamoylchloride | HCID 53399206 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | (E)-3,4-Dimethoxystyryl-1-(2-pyridyl)-1H-benzimidazole oxalate | HCID 69914538 | — |
반응 단계
Free base of the titled compound was prepared from N-(2-pyridyl)-o-phenylenediamine and 3,4-dimethoxycinnamoyl chloride (Ramamurthy, B.; Sugumaran, M. Synthesis, 1987, 523) according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A). The free base and oxalic acid were dissolved into ethyl acetate. Concentration and recrystallization from ethyl acetate/n-hexane yielded the titled compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06310079B1 |
| 출처 데이터셋 | uspto-grants-2001_10 |
| ORD ID | ord-703a92826bf54efe8e7f23d7dcd68d88 |
| 출처 메모 | uspto-grants-2001_10 |