Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3,4-dihydro-2H-pyran → 2H-Pyran, tetrahydro-2-[4-(trifluoromethyl)phenoxy]-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| 반응물 | 4-(Trifluoromethyl)phenol | HCID 67874 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2H-Pyran, tetrahydro-2-[4-(trifluoromethyl)phenoxy]- | HCID 11357015 | 133.3% |
반응 단계
A solution of 4-(Trifluoromethyl)-phenol (40 g) in dichloromethane (100 ml) was added at 0° C. dropwise to a solution of dihydropyran (53 g) in dichloromethane (100 ml) and aqueous HCl (200 μl) The reaction was allowed to reach room temperature, then quenched with saturated sodium bicarbonate (×1). The organic layer was separated and dried (MgSO4), concentrated in vacuo to give the sub-title compound (81 g)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524715B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-974d465cc163410786a446a46acbbc0e |
| 출처 메모 | uspto-grants-2013_09 |